The Cost of Innovation and Evidence in Cardiac Surgery. uri icon

Overview

abstract

  • This review summarizes a systematic analysis of 216 randomized trials of cardiovascular interventions performed during 2008-2019, according to the source of trial funding. The systematic analysis showed that on average the results of each trial would change significance if only 5 patients experienced different outcomes. Industry-sponsored trials were more likely to use composite endpoints, noninferiority designs, and twice as likely as nonindustry trials to report results favoring the device arm. Over 80% of industry trials used reporting strategies or "spin" suggesting the device arm was advantageous versus fewer than half of non-industry trials. The review discusses the implications of these findings.

publication date

  • January 1, 2020

Research

keywords

  • Cardiac Surgical Procedures
  • Cardiovascular Diseases
  • Health Care Costs
  • Inventions

Identity

Scopus Document Identifier

  • 85094810958

Digital Object Identifier (DOI)

  • 10.1177/1556984520947487

PubMed ID

  • 33108935

Additional Document Info

volume

  • 15

issue

  • 5