Robust alternative to the righting reflex to assess arousal in rodents. Academic Article uri icon

Overview

abstract

  • The righting reflex (RR) is frequently used to assess level of arousal and applied to animal models of a range of neurological disorders. RR produces a binary result that, when positive, is used to infer restoration of consciousness, often without further behavioral corroboration. We find that RR is an unreliable metric for arousal/recovery of consciousness. Instead, cortical activity and motor behavior that accompany RR are a non-binary, superior criterion that accurately calibrates and establishes level of arousal in rodents.

publication date

  • November 20, 2020

Research

keywords

  • Arousal
  • Behavior Observation Techniques
  • Nervous System Diseases
  • Reflex, Righting

Identity

PubMed Central ID

  • PMC7679463

Scopus Document Identifier

  • 85096342202

Digital Object Identifier (DOI)

  • 10.1097/01.anes.0000270741.33766.24

PubMed ID

  • 33219247

Additional Document Info

volume

  • 10

issue

  • 1