Immunomodulation by targeted anticancer agents. Review uri icon

Overview

abstract

  • At odds with conventional chemotherapeutics, targeted anticancer agents are designed to inhibit precise molecular alterations that support oncogenesis or tumor progression. Despite such an elevated degree of molecular specificity, many clinically employed and experimental targeted anticancer agents also mediate immunostimulatory or immunosuppressive effects that (at least in some settings) influence therapeutic efficacy. Here, we discuss the main immunomodulatory effects of targeted anticancer agents and explore potential avenues to harness them in support of superior clinical efficacy.

publication date

  • December 17, 2020

Research

keywords

  • Antineoplastic Agents
  • Immunomodulation
  • Neoplasms

Identity

Scopus Document Identifier

  • 85099254821

Digital Object Identifier (DOI)

  • 10.1016/j.ccell.2020.11.009

PubMed ID

  • 33338426

Additional Document Info

volume

  • 39

issue

  • 3