Bacteriophage Treatment: Critical Evaluation of Its Application on World Health Organization Priority Pathogens. Review uri icon

Overview

abstract

  • Bacteriophages represent an effective, natural, and safe strategy against bacterial infections. Multiple studies have assessed phage therapy's efficacy and safety as an alternative approach to combat the emergence of multi drug-resistant pathogens. This systematic review critically evaluates and summarizes published articles on phages as a treatment option for Staphylococcus aureus, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Enterococcus faecalis infection models. It also illustrates appropriate phage selection criteria, as well as recommendations for successful therapy. Published studies included in this review were identified through EMBASE, PubMed, and Web of Science databases and were published in the years between 2010 to 2020. Among 1082 identified articles, 29 studies were selected using specific inclusion and exclusion criteria and evaluated. Most studies (93.1%) showed high efficacy and safety for the tested phages, and a few studies also examined the effect of phage therapy combined with antibiotics (17.2%) and resistance development (27.6%). Further clinical studies, phage host identification, and regulatory processes are required to evaluate phage therapy's safety and efficacy and advance their clinical use.

publication date

  • December 30, 2020

Research

keywords

  • Bacteriophages
  • Phage Therapy

Identity

PubMed Central ID

  • PMC7823271

Scopus Document Identifier

  • 85099332090

Digital Object Identifier (DOI)

  • 10.1111/1462-2920.13284

PubMed ID

  • 33396965

Additional Document Info

volume

  • 13

issue

  • 1