Plasma cells are enriched in localized prostate cancer in Black men and are associated with improved outcomes. Academic Article uri icon

Overview

abstract

  • Black men die more often of prostate cancer yet, interestingly, may derive greater survival benefits from immune-based treatment with sipuleucel-T. Since no signatures of immune-responsiveness exist for prostate cancer, we explored race-based immune-profiles to identify vulnerabilities. Here we show in multiple independent cohorts comprised of over 1,300 patient samples annotated with either self-identified race or genetic ancestry, prostate tumors from Black men or men of African ancestry have increases in plasma cell infiltrate and augmented markers of NK cell activity and IgG expression. These findings are associated with improved recurrence-free survival following surgery and nominate plasma cells as drivers of prostate cancer immune-responsiveness.

publication date

  • February 10, 2021

Research

keywords

  • Plasma Cells
  • Prostatic Neoplasms

Identity

PubMed Central ID

  • PMC7876147

Scopus Document Identifier

  • 85101047515

Digital Object Identifier (DOI)

  • 10.1200/JCO.2016.70.2811

PubMed ID

  • 33568675

Additional Document Info

volume

  • 12

issue

  • 1