Liver Metastasis Irradiation Can Restore Immunotherapeutic Responsiveness. uri icon

Overview

abstract

  • Allogeneic liver transplants tolerize the immune system, preventing organ rejection from the same donor. A recent article by Yu et al. shows that liver metastases can likewise prevent tumor rejection in immunotherapy-treated murine and human hosts. Furthermore, radiation can reprogram the liver microenvironment to restore systemic tumor rejection.

publication date

  • February 23, 2021

Research

keywords

  • Liver Neoplasms
  • T-Lymphocytes

Identity

Scopus Document Identifier

  • 85101315562

Digital Object Identifier (DOI)

  • 10.1016/j.it.2021.02.007

PubMed ID

  • 33637449

Additional Document Info

volume

  • 42

issue

  • 4