Plasma anti-CD4 IgG is associated with brain abnormalities in people with HIV on antiretroviral therapy. Academic Article uri icon

Overview

abstract

  • Anti-CD4 IgG autoantibodies have been implicated in CD4+ T cell reconstitution failure, leaving people with HIV (PWH) at heightened risk of HIV-associated comorbidities, such as neurocognitive impairment. Seventeen PWH on stable anti-retroviral therapy (ART) and 10 HIV seronegative controls had plasma anti-CD4 IgG antibodies measured by enzyme-linked immunosorbent assay. Neuropsychological (NP) tests assessed cognitive performance, and brain volumes were measured by structural magnetic resonance imaging. Anti-CD4 IgG levels were elevated (p = 0.04) in PWH compared with controls. Anti-CD4 IgG correlated with global NP z-scores (rho = - 0.51, p = 0.04). A relationship was observed between anti-CD4 IgG and putamen (β = - 0.39, p = 0.02), pallidum (β = - 0.38, p = 0.03), and amygdala (β = - 0.42, p = 0.05) regional brain volumes. The results of this study suggest the existence of an antibody-mediated relationship with neurocognitive impairment and brain abnormalities in an HIV-infected population.

publication date

  • March 12, 2021

Research

keywords

  • AIDS Dementia Complex
  • Autoantibodies
  • CD4 Antigens
  • CD4-Positive T-Lymphocytes
  • Cognitive Dysfunction

Identity

Scopus Document Identifier

  • 85102577535

Digital Object Identifier (DOI)

  • 10.1097/QAD.0000000000001103

PubMed ID

  • 33710596

Additional Document Info

volume

  • 27

issue

  • 2