The roles and regulation of MDM2 and MDMX: it is not just about p53. Review uri icon

Overview

abstract

  • Most well studied as proteins that restrain the p53 tumor suppressor protein, MDM2 and MDMX have rich lives outside of their relationship to p53. There is much to learn about how these two proteins are regulated and how they can function in cells that lack p53. Regulation of MDM2 and MDMX, which takes place at the level of transcription, post-transcription, and protein modification, can be very intricate and is context-dependent. Equally complex are the myriad roles that these two proteins play in cells that lack wild-type p53; while many of these independent outcomes are consistent with oncogenic transformation, in some settings their functions could also be tumor suppressive. Since numerous small molecules that affect MDM2 and MDMX have been developed for therapeutic outcomes, most if not all designed to prevent their restraint of p53, it will be essential to understand how these diverse molecules might affect the p53-independent activities of MDM2 and MDMX.

publication date

  • April 22, 2021

Research

keywords

  • Gene Expression Regulation, Neoplastic
  • Proto-Oncogene Proteins c-mdm2
  • Tumor Suppressor Protein p53

Identity

PubMed Central ID

  • PMC8091979

Scopus Document Identifier

  • 85105994467

Digital Object Identifier (DOI)

  • 10.4049/jimmunol.0803693

PubMed ID

  • 33888565

Additional Document Info

volume

  • 35

issue

  • 9-10