Investigation of triple-negative breast cancer risk alleles in an International African-enriched cohort. Academic Article uri icon

Overview

abstract

  • Large-scale efforts to identify breast cancer (BC) risk alleles have historically taken place among women of European ancestry. Recently, there are new efforts to verify if these alleles increase risk in African American (AA) women as well. We investigated the effect of previously reported AA breast cancer and triple-negative breast cancer (TNBC) risk alleles in our African-enriched International Center for the Study of Breast Cancer Subtypes (ICSBCS) cohort. Using case-control, case-series and race-nested approaches, we report that the Duffy-null allele (rs2814778) is associated with TNBC risk (OR = 3.814, p = 0.001), specifically among AA individuals, after adjusting for self-indicated race and west African ancestry (OR = 3.368, p = 0.007). We have also validated the protective effect of the minor allele of the ANKLE1 missense variant rs2363956 among AA for TNBC (OR = 0.420, p = 0.005). Our results suggest that an ancestry-specific Duffy-null allele and differential prevalence of a polymorphic gene variant of ANKLE1 may play a role in TNBC breast cancer outcomes. These findings present opportunities for therapeutic potential and future studies to address race-specific differences in TNBC risk and disease outcome.

authors

publication date

  • April 29, 2021

Research

keywords

  • Black People
  • Duffy Blood-Group System
  • Endonucleases
  • Receptors, Cell Surface
  • Triple Negative Breast Neoplasms
  • White People

Identity

PubMed Central ID

  • PMC8085076

Scopus Document Identifier

  • 85105099578

Digital Object Identifier (DOI)

  • 10.1002/jcc.20084

PubMed ID

  • 33927264

Additional Document Info

volume

  • 11

issue

  • 1