Afferent and Efferent Neuro-Ophthalmic Complications of Coronavirus Disease 19. Review uri icon

Overview

abstract

  • PURPOSE: To provide a summary of the neuro-ophthalmic manifestations of coronavirus disease 19 (COVID-19) documented in the literature thus far. METHODS: The PubMed and Google Scholar databases were searched using the keywords: Neuro-Ophthalmology, COVID-19, SARS-CoV-2, and coronavirus. A manual search through reference lists of relevant articles was also performed. RESULTS/CONCLUSIONS: The literature on COVID-associated neuro-ophthalmic disease continues to grow. Afferent neuro-ophthalmic complications associated with COVID-19 include optic neuritis, papillophlebitis, papilledema, visual disturbance associated with posterior reversible encephalopathy syndrome, and vision loss caused by stroke. Efferent neuro-ophthalmic complications associated with COVID-19 include cranial neuropathies, Miller Fisher syndrome, Adie's pupils, ocular myasthenia gravis, nystagmus and eye movement disorders. Proposed mechanisms of neurologic disease include immunologic upregulation, vasodilation and vascular permeability, endothelial dysfunction, coagulopathy, and direct viral neurotropism. When patients present to medical centers with new onset neuro-ophthalmic conditions during the pandemic, COVID-19 infection should be kept on the differential.

publication date

  • June 1, 2021

Research

keywords

  • COVID-19
  • Optic Neuritis
  • Pandemics
  • Posterior Leukoencephalopathy Syndrome
  • SARS-CoV-2

Identity

Scopus Document Identifier

  • 85106545610

Digital Object Identifier (DOI)

  • 10.1097/WNO.0000000000001276

PubMed ID

  • 33935220

Additional Document Info

volume

  • 41

issue

  • 2