Glutathione S-Transferases in Cancer. Review uri icon

Overview

abstract

  • In humans, the glutathione S-transferases (GST) protein family is composed of seven members that present remarkable structural similarity and some degree of overlapping functionalities. GST proteins are crucial antioxidant enzymes that regulate stress-induced signaling pathways. Interestingly, overactive GST proteins are a frequent feature of many human cancers. Recent evidence has revealed that the biology of most GST proteins is complex and multifaceted and that these proteins actively participate in tumorigenic processes such as cell survival, cell proliferation, and drug resistance. Structural and pharmacological studies have identified various GST inhibitors, and these molecules have progressed to clinical trials for the treatment of cancer and other diseases. In this review, we discuss recent findings in GST protein biology and their roles in cancer development, their contribution in chemoresistance, and the development of GST inhibitors for cancer treatment.

publication date

  • April 29, 2021

Identity

PubMed Central ID

  • PMC8146591

Scopus Document Identifier

  • 84870039704

Digital Object Identifier (DOI)

  • 10.1371/journal.pone.0050587

PubMed ID

  • 33946704

Additional Document Info

volume

  • 10

issue

  • 5