Effects of Chronic Secondhand Smoke (SHS) Exposure on Cognitive Performance and Metabolic Pathways in the Hippocampus of Wild-Type and Human Tau Mice. Academic Article uri icon

Overview

abstract

  • BACKGROUND: Exposure to secondhand smoke (SHS) is a risk factor for developing sporadic forms of sporadic dementia. A human tau (htau) mouse model is available that exhibits age-dependent tau dysregulation, neurofibrillary tangles, neuronal loss, neuroinflammation, and oxidative stress starting at an early age (3-4 months) and in which tau dysregulation and neuronal loss correlate with synaptic dysfunction and cognitive decline. OBJECTIVE: ∼ METHODS: Wild-type (WT) and htau female and male mice were exposed to SHS (90% side stream, 10% main stream) using the SCIREQ® inExpose™ system or air control for 168 min per day, for 312 d, 7 d per week. The exposures continued during the days of behavioral and cognitive testing. In addition to behavioral and cognitive performance and neuropathology, the lungs of mice were examined for pathology and alterations in gene expression. RESULTS: IGF DISCUSSION: The brain of WT mice, in particular WT male mice, might be especially susceptible to the effects of chronic SHS exposure. In WT males, independent pathways involving ascorbate, flavin adenine dinucleotide, or palmitoleic acid might contribute to the hippocampal injury following chronic SHS exposure. https://doi.org/10.1289/EHP8428.

authors

  • Raber, Jacob
  • Perez, Ruby
  • Torres, Eileen Ruth
  • Krenik, Destine
  • Boutros, Sydney
  • Patel, Esha
  • Chlebowski, Anna C
  • Torres, Estefania Ramos
  • Perveen, Zakia
  • Penn, Arthur
  • Paulsen, Daniel B
  • Bartlett, Michael G
  • Jia, Enze
  • Holden, Sarah
  • Hall, Reed
  • Morré, Jeffrey
  • Wong, Carmen
  • Ho, Emily
  • Choi, Jaewoo
  • Stevens, Jan Frederik
  • Noël, Alexandra
  • Bobe, Gerd
  • Kisby, Glen

publication date

  • May 19, 2021

Research

keywords

  • Environmental Exposure
  • Hippocampus
  • Tobacco Smoke Pollution

Identity

PubMed Central ID

  • PMC8132614

Scopus Document Identifier

  • 85107085703

Digital Object Identifier (DOI)

  • 10.3233/JAD-150751

PubMed ID

  • 34009016

Additional Document Info

volume

  • 129

issue

  • 5