Hepatocellular carcinoma: metastatic pathways and extra-hepatic findings. Review uri icon

Overview

abstract

  • Although a small portion of patients with hepatocellular carcinoma (HCC) have radiologically evident extrahepatic disease at the initial presentation, a larger number of them develop metastatic disease later during the course of treatment or after definitive treatment. Furthermore, early metastatic disease could be overlooked by imaging due to small size and non-specificity of findings. Extrahepatic spread of HCC occurs via different pathways and is directly fueled by tumor biology and its molecular characteristics. Early and accurate detection of extrahepatic disease in patients with HCC has significant impact on management and selection of treatment options. Additionally, precise staging of disease will allow for better prediction of survival and outcome. Different pathways of regional and systemic spread of HCC with their proposed mechanisms and relevant underlying molecular derangement will be discussed in this article. Potential roles in management of patients with HCC will be discussed and reviewed in this article.

publication date

  • June 5, 2021

Research

keywords

  • Carcinoma, Hepatocellular
  • Liver Neoplasms
  • Lung Neoplasms

Identity

Scopus Document Identifier

  • 85107461958

Digital Object Identifier (DOI)

  • 10.1093/annonc/mdn786

PubMed ID

  • 34091729

Additional Document Info

volume

  • 46

issue

  • 8