Higher Serum Urate Levels Are Associated With an Increased Risk for Sudden Cardiac Death. Academic Article uri icon

Overview

abstract

  • OBJECTIVE: To determine the association of serum urate (SU) levels with sudden cardiac death and incident coronary heart disease (CHD), separately, among adults without a history of CHD. METHODS: We conducted a case-cohort analysis of Black and White participants aged ≥ 45 years enrolled in the REason for Geographic And Racial Differences in Stroke (REGARDS) study without a history of CHD at baseline between 2003 and 2007. Participants were followed for sudden cardiac death or incident CHD (i.e., myocardial infarction [MI] or death from CHD excluding sudden cardiac death) through December 31, 2013. Baseline SU was measured in a random sample of participants (n = 840) and among participants who experienced sudden cardiac death (n = 235) or incident CHD (n = 851) during follow-up. RESULTS: Participants with higher SU levels were older and more likely to be male or Black. The crude HR (95% CI) per 1 mg/dL higher SU level was 1.26 (1.14-1.40) for sudden cardiac death and 1.17 (1.09-1.26) for incident CHD. After adjustment for age, sex, race, and cardiovascular risk factors, the HR (95% CI) per 1 mg/dL higher SU level was 1.19 (1.03-1.37) for sudden cardiac death and 1.05 (0.96-1.15) for incident CHD. HRs for sudden cardiac death were numerically higher among participants aged 45-64 vs ≥ 65 years, without vs with diabetes, and among those of White vs Black race, although P values for effect modification were all ≥ 0.05. CONCLUSION: Higher SU levels were associated with an increased risk for sudden cardiac death but not with incident CHD.

publication date

  • June 15, 2021

Research

keywords

  • Coronary Disease
  • Uric Acid

Identity

PubMed Central ID

  • PMC8563440

Scopus Document Identifier

  • 85120066233

Digital Object Identifier (DOI)

  • 10.3899/jrheum.210139

PubMed ID

  • 34329187

Additional Document Info

volume

  • 48

issue

  • 11