Previous exposure to dengue virus is associated with increased Zika virus burden at the maternal-fetal interface in rhesus macaques. Academic Article uri icon

Overview

abstract

  • Concerns have arisen that pre-existing immunity to dengue virus (DENV) could enhance Zika virus (ZIKV) disease, due to the homology between ZIKV and DENV and the observation of antibody-dependent enhancement (ADE) among DENV serotypes. To date, no study has examined the impact of pre-existing DENV immunity on ZIKV pathogenesis during pregnancy in a translational non-human primate model. Here we show that macaques with a prior DENV-2 exposure had a higher burden of ZIKV vRNA in maternal-fetal interface tissues as compared to DENV-naive macaques. However, pre-existing DENV immunity had no detectable impact on ZIKV replication kinetics in maternal plasma, and all pregnancies progressed to term without adverse outcomes or gross fetal abnormalities detectable at delivery. Understanding the risks of ADE to pregnant women worldwide is critical as vaccines against DENV and ZIKV are developed and licensed and as DENV and ZIKV continue to circulate.

authors

  • Crooks, Chelsea
  • Weiler, Andrea M
  • Rybarczyk, Sierra L
  • Bliss, Mason I
  • Jaeger, Anna S
  • Murphy, Megan E
  • Simmons, Heather A
  • Mejia, Andres
  • Fritsch, Michael K
  • Hayes, Jennifer M
  • Eickhoff, Jens C
  • Mitzey, Ann M
  • Razo, Elaina
  • Braun, Katarina M
  • Brown, Elizabeth A
  • Yamamoto, Keisuke
  • Shepherd, Phoenix M
  • Possell, Amber
  • Weaver, Kara
  • Antony, Kathleen M
  • Morgan, Terry K
  • Newman, Christina M
  • Dudley, Dawn M
  • Schultz-Darken, Nancy
  • Peterson, Eric
  • Katzelnick, Leah C
  • Balmaseda, Angel
  • Harris, Eva
  • O'Connor, David H
  • Mohr, Emma L
  • Golos, Thaddeus G
  • Friedrich, Thomas C
  • Aliota, Matthew T

publication date

  • July 30, 2021

Research

keywords

  • Dengue
  • Dengue Virus
  • Maternal-Fetal Exchange
  • Zika Virus
  • Zika Virus Infection

Identity

PubMed Central ID

  • PMC8357128

Scopus Document Identifier

  • 85112332143

Digital Object Identifier (DOI)

  • 10.1126/science.aaf8505

PubMed ID

  • 34329306

Additional Document Info

volume

  • 15

issue

  • 7