Multi-scale network targeting: A holistic systems-biology approach to cancer treatment. Academic Article uri icon

Overview

abstract

  • The vulnerabilities of cancer at the cellular and, recently, with the introduction of immunotherapy, at the tissue level, have been exploited with variable success. Evaluating the cancer system vulnerabilities at the organismic level through analysis of network topology and network dynamics can potentially predict novel anti-cancer drug targets directed at the macroscopic cancer networks. Theoretical work analyzing the properties and the vulnerabilities of the multi-scale network of cancer needs to go hand-in-hand with experimental research that uncovers the biological nature of the relevant networks and reveals new targetable vulnerabilities. It is our hope that attacking cancer on different spatial scales, in a concerted integrated approach, may present opportunities for novel ways to prevent treatment resistance.

publication date

  • August 21, 2021

Research

keywords

  • Neoplasms
  • Systems Biology

Identity

Scopus Document Identifier

  • 85114716958

Digital Object Identifier (DOI)

  • 10.1016/j.pbiomolbio.2021.08.004

PubMed ID

  • 34428429

Additional Document Info

volume

  • 165