Diagnosis and management of an endometrial cancer patient with Cowden syndrome. uri icon

Overview

abstract

  • Somatic PTEN alterations are common in endometrial carcinoma (EC), but in rare cases PTEN mutations are associated with inherited syndromes. Here, we present a case of Cowden syndrome-associated EC. We discuss clinical, pathologic and molecular features of her tumor and PTEN-mutated EC, inherited syndromes predisposing to EC and PTEN-targeted therapies.

publication date

  • August 23, 2021

Research

keywords

  • Endometrial Neoplasms
  • Hamartoma Syndrome, Multiple
  • Mutation
  • PTEN Phosphohydrolase

Identity

PubMed Central ID

  • PMC8515352

Scopus Document Identifier

  • 85113384193

Digital Object Identifier (DOI)

  • 10.1016/j.ygyno.2021.08.008

PubMed ID

  • 34446268

Additional Document Info

volume

  • 163

issue

  • 1