The prohibitin-binding compound fluorizoline inhibits mitophagy in cancer cells. Academic Article uri icon

Overview

abstract

  • Fluorizoline is a prohibitin-binding compound that triggers apoptosis in several cell lines from murine and human origin, as well as in primary cells from hematologic malignancies by inducing the integrated stress response and ER stress. Recently, it was described that PHB (Prohibitin) 1 and 2 are crucial mitophagy receptors involved in mediating the autophagic degradation of mitochondria. We measured mitophagy in HeLa cells expressing Parkin and in A549, a lung cancer cell line that can undergo mitophagy in a Parkin-independent manner, and we demonstrated that both fluorizoline and rocaglamide A, another PHB-binding molecule, inhibit CCCP- and OA-induced mitophagy. Moreover, we demonstrated that PHBs are mediating Parkin-dependent mitophagy. In conclusion, besides being a potent pro-apoptotic compound, we present fluorizoline as a promising new mitophagy modulator that could be used as anticancer agent.

publication date

  • September 27, 2021

Identity

PubMed Central ID

  • PMC8476632

Scopus Document Identifier

  • 84943745182

Digital Object Identifier (DOI)

  • 10.1080/15548627.2015.1056970

PubMed ID

  • 34580273

Additional Document Info

volume

  • 10

issue

  • 9