Immunological configuration of ovarian carcinoma: features and impact on disease outcome. Review uri icon

Overview

abstract

  • Epithelial ovarian carcinoma (EOC) is a relatively rare malignancy but is the fifth-leading cause of cancer-related death in women, largely reflecting early, prediagnosis dissemination of malignant disease to the peritoneum. At odds with other neoplasms, EOC is virtually insensitive to immune checkpoint inhibitors, correlating with a tumor microenvironment that exhibits poor infiltration by immune cells and active immunosuppression. Here, we comparatively summarize the humoral and cellular features of primary and metastatic EOC, comparatively analyze their impact on disease outcome, and propose measures to alter them in support of treatment sensitivity and superior patient survival.

publication date

  • October 1, 2021

Research

keywords

  • Carcinoma, Ovarian Epithelial
  • Immunosuppression Therapy
  • Immunotherapy

Identity

PubMed Central ID

  • PMC8515436

Scopus Document Identifier

  • 85117488650

Digital Object Identifier (DOI)

  • 10.3892/or.2018.6311

PubMed ID

  • 34645669

Additional Document Info

volume

  • 9

issue

  • 10