Rejuvenating dysfunctional T cells in ovarian cancer: CD28 is the license to kill. uri icon

Overview

abstract

  • High-grade serous ovarian cancers (HGSOCs) exhibit limited response to immune checkpoint blockade. In a new study in Cancer Cell, Duraiswamy et al. highlight intratumoral CD28 co-stimulation by myeloid-antigen-presenting cells as a key mechanism required for activation of programmed cell death receptor 1 (PD-1)+ tumor-infiltrating T lymphocytes during PD-1 blockade in HGSOC.

publication date

  • November 4, 2021

Research

keywords

  • CD28 Antigens
  • Ovarian Neoplasms

Identity

Scopus Document Identifier

  • 85122771505

Digital Object Identifier (DOI)

  • 10.1016/j.ccell.2021.10.011

PubMed ID

  • 34739843

Additional Document Info

volume

  • 39

issue

  • 12