MicroRNA-29 specifies age-related differences in the CD8+ T cell immune response. Academic Article uri icon

Overview

abstract

  • MicroRNAs (miRNAs) have emerged as critical regulators of cell fate in the CD8+ T cell response to infection. Although there are several examples of miRNAs acting on effector CD8+ T cells after infection, it is unclear whether differential expression of one or more miRNAs in the naive state is consequential in altering their long-term trajectory. To answer this question, we examine the role of miR-29 in neonatal and adult CD8+ T cells, which express different amounts of miR-29 only prior to infection and adopt profoundly different fates after immune challenge. We find that manipulation of miR-29 expression in the naive state is sufficient for age-adjusting the phenotype and function of CD8+ T cells, including their regulatory landscapes and long-term differentiation trajectories after infection. Thus, miR-29 acts as a developmental switch by controlling the balance between a rapid effector response in neonates and the generation of long-lived memory in adults.

authors

  • Yee Mon, Kristel
  • Zhu, Hongya
  • Daly, Ciarán W P
  • Vu, Luyen T
  • Smith, Norah L
  • Patel, Ravi
  • Topham, David J
  • Scheible, Kristin
  • Jambo, Kondwani
  • Le, Minh T N
  • Rudd, Brian D
  • Grimson, Andrew

publication date

  • November 9, 2021

Research

keywords

  • CD8-Positive T-Lymphocytes
  • Immunologic Memory
  • Listeriosis
  • Lymphocyte Activation
  • MicroRNAs

Identity

Scopus Document Identifier

  • 85118875732

Digital Object Identifier (DOI)

  • 10.1016/j.celrep.2021.109969

PubMed ID

  • 34758312

Additional Document Info

volume

  • 37

issue

  • 6