Using epigenetic modifiers to target cancer stem cell immunoevasion. uri icon

Overview

abstract

  • Two recent reports in Nature highlight a novel mechanism of immunoevasion that relies on the SET domain bifurcated histone lysine methyltransferase 1 (SETDB1)-dependent epigenetic suppression of endogenous retroelements in melanoma cells. Because SETDB1 is highly expressed by the stem cell compartment, these findings delineate an innovative strategy for restoring cancer stem cell immunosurveillance.

publication date

  • December 13, 2021

Research

keywords

  • Neoplasms

Identity

Scopus Document Identifier

  • 85122843504

Digital Object Identifier (DOI)

  • 10.1016/j.ccell.2021.11.003

PubMed ID

  • 34906316

Additional Document Info

volume

  • 39

issue

  • 12