Prognostic markers in invasive bladder cancer: FGFR3 mutation status versus P53 and KI-67 expression: a multi-center, multi-laboratory analysis in 1058 radical cystectomy patients. Academic Article uri icon

Overview

abstract

  • OBJECTIVES: To determine the association between the FGFR3 mutation status and immuno-histochemistry (IHC) markers (p53 and Ki-67) in invasive bladder cancer (BC), and to analyze their prognostic value in a multicenter, multi-laboratory radical cystectomy (RC) cohort. PATIENTS AND METHODS: We included 1058 cN0M0, chemotherapy-naive BC patients who underwent RC with pelvic lymph-node dissection at 8 hospitals. The specimens were reviewed by uro-pathologists. Mutations in the FGFR3 gene were examined using PCR-SNaPshot; p53 and Ki-67 expression were determined by standard IHC. FGFR3 mutation status as well as p53 (cut-off>10%) and Ki-67 (cut-off>20%) expression were correlated to clinicopathological parameters and disease specific survival (DSS). RESULTS: pT-stage was

authors

  • Mertens, Laura S
  • Claps, Francesco
  • Mayr, Roman
  • Bostrom, Peter J
  • Shariat, Shahrokh
  • Zwarthoff, Ellen C
  • Boormans, Joost L
  • Abas, Cheno
  • van Leenders, Geert J L H
  • Götz, Stefanie
  • Hippe, Katrin
  • Bertz, Simone
  • Neuzillet, Yann
  • Sanders, Joyce
  • Broeks, Annegien
  • Peters, Dennis
  • van der Heijden, Michiel S
  • Jewett, Michael A S
  • Stöhr, Robert
  • Zlotta, Alexandre R
  • Eckstein, Markus
  • Soorojebally, Yanish
  • van der Schoot, Deric K E
  • Wullich, Bernd
  • Burger, Maximilian
  • Otto, Wolfgang
  • Radvanyi, François
  • Sirab, Nanour
  • Pouessel, Damien
  • van der Kwast, Theo H
  • Hartmann, Arndt
  • Lotan, Yair
  • Allory, Yves
  • Zuiverloon, Tahlita C M
  • van Rhijn, Bas W G

publication date

  • December 11, 2021

Research

keywords

  • Tumor Suppressor Protein p53
  • Urinary Bladder Neoplasms

Identity

Scopus Document Identifier

  • 85120990866

Digital Object Identifier (DOI)

  • 10.1016/j.urolonc.2021.10.010

PubMed ID

  • 34906411

Additional Document Info

volume

  • 40

issue

  • 3