Hypocomplementemia with low C1s-C1 inhibitor complex in systemic lupus erythematosus. Academic Article uri icon

Overview

abstract

  • Ninety-three serum and plasma samples from 45 patients with systemic lupus erythematosus were analyzed for the complex formed by C1s and its inhibitor, as well as for C3, C4, C4a desarginine, and staphylococcal protein A-bound immune complexes. There were statistically significant correlations between C1s-C1 inhibitor complex and CH50, between C1s-C1 inhibitor complex and C4, and between C1s-C1 inhibitor complex and C4a desarginine. Serial studies were performed on 24 patients over a period of 6 months. Seven of 21 patients with hypocomplementemia had persistently normal levels of C1s-C1 inhibitor complex, 7 had transiently abnormal levels of C1s-C1 inhibitor complex, and 7 had sustained abnormal levels of C1s-C1 inhibitor complex. Two of 3 pregnant patients with normal levels of complement had abnormal levels of C1s-C1 inhibitor complex. Staphylococcal protein A-bound immune complexes demonstrated no correlation with any of the complement assays. Complement activation, as measured by C1s-C1 inhibitor complex, is often a transient phenomenon in systemic lupus erythematosus patients with persistent hypocomplementemia.

publication date

  • December 1, 1986

Research

keywords

  • Complement C1 Inactivator Proteins
  • Complement System Proteins
  • Lupus Erythematosus, Systemic

Identity

Scopus Document Identifier

  • 0022902638

Digital Object Identifier (DOI)

  • 10.1002/art.1780291207

PubMed ID

  • 3492208

Additional Document Info

volume

  • 29

issue

  • 12