Imipramine and amitriptyline plasma concentrations and clinical response in major depression. Academic Article uri icon

Overview

abstract

  • Plasma drug concentrations and clinical response were measured in two groups of hospitalised depressed patients, who received amitriptyline or imipramine double-blind, in a dosage of 250 mg for four weeks. Virtually no significant linear or curvilinear relationships were found between any plasma measure and any measure of clinical response. Modest but significant direct relationships were found between age and concentration of parent drugs but not demethylated metabolites. Blood drug level measurement therefore appears to be of little value in monitoring drug treatment of depressed in-patients.

publication date

  • January 1, 1986

Research

keywords

  • Amitriptyline
  • Depressive Disorder
  • Imipramine

Identity

Scopus Document Identifier

  • 0022643887

Digital Object Identifier (DOI)

  • 10.1192/bjp.148.1.52

PubMed ID

  • 3513884

Additional Document Info

volume

  • 148