Platinum-based chemotherapy inflames the ovarian carcinoma microenvironment through cellular senescence. Editorial Article uri icon

Overview

abstract

  • Epithelial ovarian carcinoma (EOC) is virtually insensitive to immune checkpoint inhibitors (ICIs). Recent findings from an innovative mouse model of EOC demonstrate that senescence induction underlies the increased sensitivity of homologous recombination-defective EOCs to platinum-based chemotherapy as it initiates tumor infiltration by immune effector cells coupled to restored sensitivity to ICIs.

publication date

  • March 17, 2022

Research

keywords

  • Ovarian Neoplasms

Identity

PubMed Central ID

  • PMC8932912

Scopus Document Identifier

  • 85126734621

Digital Object Identifier (DOI)

  • 10.1038/s41590-020-0751-0

PubMed ID

  • 35309729

Additional Document Info

volume

  • 11

issue

  • 1