Sex-Related Factors in Valvular Heart Disease: JACC Focus Seminar 5/7. Review uri icon

Overview

abstract

  • Numerous sex-based differences are observed across the spectrum of valvular heart disease, starting with pathophysiology and progression of disease, moving on to compensation and comorbidities (both cardiovascular such as coronary artery disease and noncardiovascular such as frailty), assessment of severity and hemodynamics including timing of intervention, and procedural risks/benefits and outcomes. The aortic valve is perhaps best understood with sex differences in both pathologic changes and response to volume and pressure overload, yet large gaps in our understanding still exist. Studies of other valve diseases have focused on differences in prevalence, presentation, and outcomes for surgical or transcatheter therapies. Defining sex-specific responses to valvular heart disease may improve disease recognition, define treatment strategies, and improve outcomes.

publication date

  • April 19, 2022

Research

keywords

  • Heart Valve Diseases
  • Heart Valve Prosthesis Implantation

Identity

Scopus Document Identifier

  • 85127066566

Digital Object Identifier (DOI)

  • 10.1016/j.jacc.2021.08.081

PubMed ID

  • 35422247

Additional Document Info

volume

  • 79

issue

  • 15