Comparison of ceforanide and cephalothin prophylaxis in patients undergoing total joint arthroplasty. Academic Article uri icon

Overview

abstract

  • One hundred one patients undergoing total hip and knee arthroplasty were randomly assigned to receive either two 1 gm doses of ceforanide or five doses of cephalothin perioperatively. Simultaneous plasma and cancellous bone specimens were obtained intraoperatively and assayed for antibiotic concentration. Ceforanide plasma and bone levels remained sustained over six hours. Cephalothin plasma and bone levels obtained three to four hours post administration were 91% lower than levels obtained one hour post-dose. Patients were examined for infection for up to 18 months following surgery. None of the patients developed an infected implant. The sustained plasma and bone levels achieved with ceforanide obviate the need for intraoperative dosing necessary with other agents.

publication date

  • December 1, 1986

Research

keywords

  • Bacterial Infections
  • Cefamandole
  • Cephalothin
  • Hip Prosthesis
  • Knee Prosthesis
  • Premedication

Identity

Scopus Document Identifier

  • 0022844899

Digital Object Identifier (DOI)

  • 10.3928/0147-7447-19861201-08

PubMed ID

  • 3547369

Additional Document Info

volume

  • 9

issue

  • 12