Immunotherapy: an alternative promising therapeutic approach against cancers. Review uri icon

Overview

abstract

  • The immune system interacts with cancer cells in multiple intricate ways that can shield the host against hyper-proliferation but can also contribute to malignancy. Understanding the protective roles of the immune system in its interaction with cancer cells can help device new and alternate therapeutic strategies. Many immunotherapeutic methodologies, including adaptive cancer therapy, cancer peptide vaccines, monoclonal antibodies, and immune checkpoint treatment, have transformed the traditional cancer treatment landscape. However, many questions remain unaddressed. The development of personalized combination therapy and neoantigen-based cancer vaccines would be the avant-garde approach to cancer treatment. Desirable chemotherapy should be durable, safe, and target-specific. Managing both tumor (intrinsic factors) and its microenvironment (extrinsic factors) are critical for successful immunotherapy. This review describes current approaches and their advancement related to monoclonal antibody-related clinical trials, new cytokine therapy, a checkpoint inhibitor, adoptive T cell therapy, cancer vaccine, and oncolytic virus.

publication date

  • June 27, 2022

Research

keywords

  • Cancer Vaccines
  • Neoplasms

Identity

PubMed Central ID

  • PMC9244230

Scopus Document Identifier

  • 85132842580

Digital Object Identifier (DOI)

  • 10.1007/s11033-021-07020-6

PubMed ID

  • 35759082

Additional Document Info

volume

  • 49

issue

  • 10