Human immune globulin treatment controls Zika viremia in pregnant rhesus macaques. Academic Article uri icon

Overview

abstract

  • There are currently no approved drugs to treat Zika virus (ZIKV) infection during pregnancy. Hyperimmune globulin products such as VARIZIG and WinRho are FDA-approved to treat conditions during pregnancy such as Varicella Zoster virus infection and Rh-incompatibility. We administered ZIKV-specific human immune globulin as a treatment in pregnant rhesus macaques one day after subcutaneous ZIKV infection. All animals controlled ZIKV viremia following the treatment and generated robust levels of anti-Zika virus antibodies in their blood. No adverse fetal or infant outcomes were identified in the treated animals, yet the placebo control treated animals also did not have signs related to congenital Zika syndrome (CZS). Human immune globulin may be a viable prophylaxis and treatment option for ZIKV infection during pregnancy, however, more studies are required to fully assess the impact of this treatment to prevent CZS.

authors

publication date

  • July 14, 2022

Research

keywords

  • Pregnancy Complications, Infectious
  • Zika Virus
  • Zika Virus Infection

Identity

PubMed Central ID

  • PMC9282477

Scopus Document Identifier

  • 85134149047

Digital Object Identifier (DOI)

  • 10.1371/journal.pone.0106393

PubMed ID

  • 35834540

Additional Document Info

volume

  • 17

issue

  • 7