Two-step recognition of HIV-1 DNA in the cytosol. Academic Article uri icon

Overview

abstract

  • Retroviral DNA induces the production of interferons. A new study by Yoh et al. showed that the host factor 'PQBP1' primes immune-recognition of retroviral DNA by recruiting the cytosolic DNA scavenger 'cGAS' to the HIV-1 capsid. Their findings support the importance of innate immune sensing in HIV-1 infection.

publication date

  • September 21, 2022

Research

keywords

  • HIV Infections
  • HIV-1

Identity

Scopus Document Identifier

  • 85138800870

Digital Object Identifier (DOI)

  • 10.1016/j.tim.2022.09.007

PubMed ID

  • 36153261

Additional Document Info

volume

  • 31

issue

  • 5