Modulation of activity of the striatal dopaminergic system during the hibernation cycle. Academic Article uri icon

Overview

abstract

  • To evaluate how the activity of a well-established neurotransmitter pathway is modulated by a behavioral state, 3H-spiperone binding sites and dopamine (DA) and DA metabolite concentrations were measured in the striata of ground squirrels in 5 phases of the hibernation cycle. Whereas levels of striatal DA and its deaminated metabolite DOPAC did not change significantly, the concentrations of the O-methylated-deaminated metabolite, homovanillic acid (HVA), decreased in all phases of hibernation relative to euthermia. Striatal 3H-spiperone binding sites declined across the hibernation cycle in parallel with the reduction of HVA concentration; receptor binding affinity was unchanged by arousal state. In conjunction with previously reported findings, these results are consistent with the hypothesis that hibernation is associated with a down-regulation of the postsynaptic D2 receptors secondary to increased extracellular DA concentration and reduced DA degradation.

publication date

  • September 1, 1987

Research

keywords

  • Corpus Striatum
  • Dopamine
  • Hibernation

Identity

PubMed Central ID

  • PMC6569135

Scopus Document Identifier

  • 0023408008

Digital Object Identifier (DOI)

  • 10.1523/JNEUROSCI.07-09-02732.1987

PubMed ID

  • 3625271

Additional Document Info

volume

  • 7

issue

  • 9