Alloimmune Neutropenia in a Neonate: Case Report and Review of Literature. uri icon

Overview

abstract

  • Neonatal alloimmune neutropenia, variably referred to in the literature as NAIN, FNAIN or NIN, is a disorder of neutrophil destruction in newborns similar to better-known conditions such as hemolytic disease of the newborn and neonatal alloimmune thrombocytopenia (FNAIT). Infants affected by this self-limiting condition can present asymptomatically or have a wide range of symptoms, from skin manifestations and mucositis to severe infections such as sepsis and pneumonia. In our case, we report an otherwise asymptomatic term infant born with severe neutropenia to a mother affected by COVID-19 in the 3rd trimester. However, it is unclear if COVID-19 contributed to our patients' neutropenia. Diagnostic testing eventually revealed the presence of anti-neutrophil antibodies, confirming the diagnosis of alloimmune neutropenia. The infant was conservatively managed with early discharge prior to resolution of neutropenia and close post-discharge follow up.

publication date

  • October 3, 2022

Identity

PubMed Central ID

  • PMC9624355

Scopus Document Identifier

  • 80053367664

Digital Object Identifier (DOI)

  • 10.1056/NEJMoa1100441

PubMed ID

  • 36278616

Additional Document Info

volume

  • 11

issue

  • 4