A Chimeric Peptide Inhibits Red Blood Cell Invasion by Plasmodium falciparum with Hundredfold Increased Efficacy. Academic Article uri icon

Overview

abstract

  • Inhibiting the formation of a tight junction between two malaria parasite proteins, apical membrane antigen 1 and rhoptry neck protein 2, crucial for red blood cell invasion, prevents progression of the disease. In this work, we have used a unique approach to design a chimeric peptide, prepared by fusion of the best features of two peptide inhibitors, that has displayed parasite growth inhibition ex vivo with nanomolar IC50 , which is 100 times better than any of its parent peptides. Furthermore, to gain structural insights, we computationally modelled the hybrid peptide on its receptor.

publication date

  • December 23, 2022

Research

keywords

  • Plasmodium falciparum
  • Protozoan Proteins

Identity

Scopus Document Identifier

  • 85144720709

Digital Object Identifier (DOI)

  • 10.1002/cbic.202200533

PubMed ID

  • 36449557

Additional Document Info

volume

  • 24

issue

  • 7