MicroRNAs within the Basal-like signature of Quadruple Negative Breast Cancer impact overall survival in African Americans. Academic Article uri icon

Overview

abstract

  • We previously found that QNBC tumors are more frequent in African Americans compared to TNBC tumors. To characterize this subtype further, we sought to determine the miRNA-mRNA profile in QNBC patients based on race. Both miRNA and mRNA expression data were analyzed from TCGA and validated using datasets from the METABRIC, TCGA proteomic, and survival analysis by KMPLOT. miRNA-mRNAs which include FOXA1 and MYC (mir-17/20a targets); GATA3 and CCNG2 (mir-135b targets); CDKN2A, CDK6, and B7-H3 (mir-29c targets); and RUNX3, KLF5, IL1-β, and CTNNB1 (mir-375 targets) were correlated with basal-like and immune subtypes in QNBC patients and associated with a worse survival. Thus, QNBC tumors have an altered gene signature implicated in racial disparity and poor survival.

publication date

  • December 22, 2022

Research

keywords

  • Breast Neoplasms
  • MicroRNAs
  • Triple Negative Breast Neoplasms

Identity

PubMed Central ID

  • PMC9780260

Scopus Document Identifier

  • 85144501357

Digital Object Identifier (DOI)

  • 10.3892/etm.2015.2477

PubMed ID

  • 36550153

Additional Document Info

volume

  • 12

issue

  • 1