Biomarker Discovery for Meta-Classification of Melanoma Metastatic Progression Using Transfer Learning. Academic Article uri icon

Overview

abstract

  • Melanoma is considered to be the most serious and aggressive type of skin cancer, and metastasis appears to be the most important factor in its prognosis. Herein, we developed a transfer learning-based biomarker discovery model that could aid in the diagnosis and prognosis of this disease. After applying it to the ensemble machine learning model, results revealed that the genes found were consistent with those found using other methodologies previously applied to the same TCGA (The Cancer Genome Atlas) data set. Further novel biomarkers were also found. Our ensemble model achieved an AUC of 0.9861, an accuracy of 91.05, and an F1 score of 90.60 using an independent validation data set. This study was able to identify potential genes for diagnostic classification (C7 and GRIK5) and diagnostic and prognostic biomarkers (S100A7, S100A7, KRT14, KRT17, KRT6B, KRTDAP, SERPINB4, TSHR, PVRL4, WFDC5, IL20RB) in melanoma. The results show the utility of a transfer learning approach for biomarker discovery in melanoma.

publication date

  • December 7, 2022

Research

keywords

  • Melanoma
  • Skin Neoplasms

Identity

PubMed Central ID

  • PMC9777873

Scopus Document Identifier

  • 85144503236

Digital Object Identifier (DOI)

  • 10.1371/journal.pone.0040267

PubMed ID

  • 36553569

Additional Document Info

volume

  • 13

issue

  • 12