Sperm DNA Damage and Its Relevance in Fertility Treatment: A Review of Recent Literature and Current Practice Guidelines. Review uri icon

Overview

abstract

  • Sperm deoxyribonucleic acid (DNA) damage has recently emerged as one of the most controversial topics in male reproductive medicine. While level I evidence indicates that abnormal sperm DNA damage has substantial adverse effects on reproductive outcomes (including chance of pregnancy and risk of miscarriage), there is limited consensus on how sperm DNA fragmentation (SDF) testing should be performed and/or interpreted in clinical practice. In this article, we review: (1) how SDF is assessed, (2) cumulative evidence regarding its impact on reproductive outcomes, (3) methods for mitigating high SDF, and (4) the most recent practice guidelines available for clinicians regarding the use and interpretation of SDF testing.

publication date

  • January 11, 2023

Research

keywords

  • Infertility, Male
  • Semen

Identity

PubMed Central ID

  • PMC9860847

Scopus Document Identifier

  • 85146776546

Digital Object Identifier (DOI)

  • 10.1016/j.fertnstert.2019.03.003

PubMed ID

  • 36674957

Additional Document Info

volume

  • 24

issue

  • 2