Five negative symptom domains are differentially associated with resting state amplitude of low frequency fluctuations in Schizophrenia. Academic Article uri icon

Overview

abstract

  • This study examined associations between resting-state amplitude of low frequency fluctuations (ALFF) and negative symptoms represented by total scores, second-order dimension (motivation and pleasure, expressivity), and first-order domain (anhedonia, avolition, asociality, alogia, blunted affect) factor scores in schizophrenia (n = 57). Total negative symptom scores showed positive associations with ALFF in temporal and frontal brain regions. Negative symptom domain scores showed predominantly stronger associations with regional ALFF compared to total scores, suggesting domain scores may better map to neural signatures than total scores. Improving our understanding of the neuropathology underlying negative symptoms may aid in addressing this unmet therapeutic need in schizophrenia.

publication date

  • January 16, 2023

Research

keywords

  • Schizophrenia

Identity

Scopus Document Identifier

  • 85146623821

Digital Object Identifier (DOI)

  • 10.1016/j.pscychresns.2023.111597

PubMed ID

  • 36680843

Additional Document Info

volume

  • 329