Cytokine Release Syndrome in the Pediatric Population and Implications for Intensive Care Management. Review uri icon

Overview

abstract

  • Cytokine release syndrome represents a spectrum of disease varying from fever alone to multiorgan system failure. Most commonly seen following treatment with chimeric antigen receptor T cell therapy, it is increasingly being described with other immunotherapies as well as following hematopoietic stem cell transplant. As its symptoms are nonspecific, awareness is key to timely diagnosis and initiation of treatment. Given the high risk of cardiopulmonary involvement, critical care providers must be familiar with the cause, symptoms, and therapeutic options. Current treatment modalities focus on immunosuppression and targeted cytokine therapy.

publication date

  • November 18, 2022

Research

keywords

  • Cytokine Release Syndrome
  • Receptors, Chimeric Antigen

Identity

Scopus Document Identifier

  • 85142366682

Digital Object Identifier (DOI)

  • 10.1016/j.ccc.2022.09.004

PubMed ID

  • 36898773

Additional Document Info

volume

  • 39

issue

  • 2