Weight loss in hypertrophic cardiomyopathy: A clinical case series. uri icon

Overview

abstract

  • BACKGROUND: Obesity is prevalent among patients with hypertrophic cardiomyopathy (HCM). Obese HCM patients have greater wall thickness, LV mass, worse hemodynamic function and NYHA class. Weight loss may favorably influence the HCM phenotype. CASE SUMMARY: We describe six patients with hypertrophic cardiomyopathy who lost weight through diet and lifestyle changes (n = 4) or bariatric surgery (n = 2). Radiographic imaging, with cardiac MRI or CT scan, was performed before and after their weight loss. There was a mean decrease in LV mass and indexed LV mass, and a mean numerical decrease in mean wall thickness in up to 14 out of 18 LV segments. There was also NYHA class reduction in symptoms. DISCUSSION: In this case series, we have shown that substantial weight loss in HCM patients can be associated with a decrease in LV mass, wall thickness and improvement in symptoms. These observations indicate the potential for positive remodeling of the heart by weight loss. Prospective studies of the benefits of weight loss in HCM are needed.

publication date

  • February 26, 2023

Identity

PubMed Central ID

  • PMC10009201

Scopus Document Identifier

  • 0028840222

Digital Object Identifier (DOI)

  • 10.1161/01.cir.92.10.2886

PubMed ID

  • 36923366

Additional Document Info

volume

  • 17