Circulating and urinary tumour DNA in urothelial carcinoma - upper tract, lower tract and metastatic disease. Review uri icon

Overview

abstract

  • Precision medicine has transformed the way urothelial carcinoma is managed. However, current practices are limited by the availability of tissue samples for genomic profiling and the spatial and temporal molecular heterogeneity observed in many studies. Among rapidly advancing genomic sequencing technologies, non-invasive liquid biopsy has emerged as a promising diagnostic tool to reproduce tumour genomics, and has shown potential to be integrated in several aspects of clinical care. In urothelial carcinoma, liquid biopsies such as plasma circulating tumour DNA (ctDNA) and urinary tumour DNA (utDNA) have been investigated as a surrogates for tumour biopsies and might bridge many shortfalls currently faced by clinicians. Both ctDNA and utDNA seem really promising in urothelial carcinoma diagnosis, staging and prognosis, response to therapy monitoring, detection of minimal residual disease and surveillance. The use of liquid biopsies in patients with urothelial carcinoma could further advance precision medicine in this population, facilitating personalized patient monitoring through non-invasive assays.

publication date

  • March 28, 2023

Research

keywords

  • Carcinoma, Transitional Cell
  • Circulating Tumor DNA
  • Urinary Bladder Neoplasms
  • Urologic Neoplasms

Identity

Scopus Document Identifier

  • 85151137449

Digital Object Identifier (DOI)

  • 10.1093/clinchem/hvaa325

PubMed ID

  • 36977797

Additional Document Info

volume

  • 20

issue

  • 7