Motor neuron disease and plasma cell dyscrasia. Academic Article uri icon

Overview

abstract

  • In the years 1977 to 1984, 10 of 206 patients (4.8%) with motor neuron disease (MND) had M proteins; 4 had IgM and 6 had IgG. Among 100 control patients with other neurologic diseases, only 1 had an M protein. We later added six cases of MND and M proteins, as well as three with polyclonal IgM elevations and two with Bence-Jones proteins. Including other reports, there are now 37 known cases of MND with monoclonal and 5 with polyclonal gammopathy. There is evidence that plasma cell dyscrasia is often undetected; the actual incidence of serum immunoglobulin abnormality in patients with MND may be greater than our figure.

publication date

  • November 1, 1986

Research

keywords

  • Amyotrophic Lateral Sclerosis
  • Motor Neurons
  • Muscular Atrophy
  • Paraproteinemias

Identity

Scopus Document Identifier

  • 0022978156

Digital Object Identifier (DOI)

  • 10.1212/wnl.36.11.1429

PubMed ID

  • 3762961

Additional Document Info

volume

  • 36

issue

  • 11