Human leukocyte antigen associations in basal cell carcinoma. Academic Article uri icon

Overview

abstract

  • Basal cell carcinoma is the most common form of skin cancer and is one in which both host and environmental factors are thought to play a role in its pathogenesis. For an investigation of the role of human leukocyte antigen (HLA)-associated variations in genetic susceptibility, thirty-one patients with multiple basal cell carcinomas were typed for HLA-A, B, C, and DR antigens. Patients were compared with both local and appropriate ethnic group controls. No statistically significant association with HLA-A, B, or C antigens was noted in any group. However, a significant increase in HLA-DR1 was noted in non-Irish, non-Ashkenazi patients. A tendency toward a decrease in HLA-DR3 was also noted among patients of Irish or Ashkenazi Jewish descent. The role of HLA-associated genetic factors in this form of skin cancer needs further investigation.

publication date

  • June 1, 1985

Research

keywords

  • Carcinoma, Basal Cell
  • HLA Antigens
  • Skin Neoplasms

Identity

Scopus Document Identifier

  • 0021823858

Digital Object Identifier (DOI)

  • 10.1016/s0190-9622(85)70127-2

PubMed ID

  • 3874217

Additional Document Info

volume

  • 12

issue

  • 6