The influence of heparin on the in vivo distribution of IN-111 labeled platelets. Academic Article uri icon

Overview

abstract

  • We investigated the influence of heparin (H) (bolus i.v.; 100-200 I.U./kg.) on the in vivo distribution and accumulation of autologous indium-111-platelets (In-111-P) on experimental pulmonary emboli (PE) in a canine model. Using a thrombin clot formation technique, we induced pulmonary emboli in ten dogs; three dogs were treated with heparin (H), and seven were not (NH). Of five control animals without PE, two were heparinized (H-control) and three were not (NH-control). Animals were sacrificed after 4 to 5 hours of serial blood sampling and sequential scintigraphy. We observed that heparin increased the recovery of In-111-P in the peripheral blood circulation of both control and PE dogs, and reduced the liver uptake of In-111-P in the PE dogs. No PE could be detected while the dogs were fully heparinized, but as the heparin effect dissipated over time, the deposition of In-111-P permitted the scintigraphic detection of PE.

publication date

  • January 1, 1985

Research

keywords

  • Blood Platelets
  • Heparin
  • Indium
  • Radioisotopes

Identity

Scopus Document Identifier

  • 0021969988

Digital Object Identifier (DOI)

  • 10.1097/00004424-198503000-00019

PubMed ID

  • 3988472

Additional Document Info

volume

  • 20

issue

  • 2