Immunohistochemical localization of dynorphin (1-8) in hypothalamic magnocellular neurons: evidence for absence of proenkephalin. Academic Article uri icon

Overview

abstract

  • Dynorphin(1-8) immunoreactivity was visualized by immunohistofluorescence in hypothalamic magnocellular neurons of the rat. No immunoreactive met-enkephalin-Arg6-Gly7-Leu8, a fragment of the adrenal medulla pro-enkephalin molecule, was detected in magnocellular neurons. However, a strong met-enkephalin-Arg6-Gly7-Leu8-like immunostaining was seen in other regions of the brain. These results suggest that in magnocellular neurons dynorphin(1-8) exists independently from pro-enkephalin and therefore the magnocellular neurons represent a third opioid peptide neuronal system in brain. These observations, however, do not rule out a coexistence of proenkephalin and dynorphin-related peptides in other regions of the brain.

publication date

  • October 1, 1982

Research

keywords

  • Endorphins
  • Hypothalamus
  • Neurons

Identity

Scopus Document Identifier

  • 0020350989

Digital Object Identifier (DOI)

  • 10.1016/0024-3205(82)90204-1

PubMed ID

  • 6130434

Additional Document Info

volume

  • 31

issue

  • 16-17