Combination chemotherapy of esophageal carcinoma using cisplatin, vindesine, and bleomycin. Academic Article uri icon

Overview

abstract

  • Sixty-one patients with epidermoid carcinoma of the esophagus have been treated with a three drug combination of cisplatin, vindesine, and bleomycin. Of 53 patients currently evaluable for response, 29 (55%) have had partial remissions: 7/16 with metastatic, and 22/37 with local-regional disease. The median duration of response in metastatic patients is eight months. Of 28 patients treated preoperatively, 23 (82%) had resectable disease. The major toxicities seen were nephrotoxicity and myelosuppression. Cisplatin, vindesine and bleomycin is an effective combination in the treatment of esophageal carcinoma. Effects on long-term survival cannot yet be evaluated.

publication date

  • March 15, 1982

Research

keywords

  • Bleomycin
  • Carcinoma, Squamous Cell
  • Cisplatin
  • Esophageal Neoplasms
  • Vinblastine

Identity

Scopus Document Identifier

  • 0020036437

Digital Object Identifier (DOI)

  • 10.1002/1097-0142(19820315)49:6<1174::aid-cncr2820490618>3.0.co;2-w

PubMed ID

  • 6174199

Additional Document Info

volume

  • 49

issue

  • 6