Distribution of norepinephrine, epinephrine, dopamine, serotonin, 3,4-dihydroxyphenylacetic acid, homovanillic acid and 5-hydroxyindole-3-acetic acid in dog brain. Academic Article uri icon

Overview

abstract

  • The distribution and endogenous concentrations of norepinephrine, epinephrine, dopamine, serotonin, 3,4-dihydroxyphenylacetic acid, homovanillic acid and 5-hydroxyindole-3-acetic acid were determined in the brains of adult dogs. Norepinephrine and epinephrine were localized primarily in 'central core' areas in brain stem and hypothalamus. Dopamine (DA) and its major metabolites, 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acids (HVA), were localized primarily in basal ganglia with relatively high concentrations also found in amygdala, septum and substantia nigra. HVA was also found in relatively high concentrations in areas where DA concentrations was very low. Serotonin and 5-hydroxyindole-3-acetic acid levels were highest in brain stem, hypothalamus, globus pallidus and nucleus accumbens. Epinephrine levels were higher than in previously studied species, at times as much as 25-30% of norepinephrine and frequently greater than dopamine in brain stem and hypothalamus. Using the ratios 5-hydroxyindole-3-acetic acid/serotonin and homovanillic acid/dopamine as indicators of serotonin and dopamine turnover and utilization, both putative transmitters were found to be generally more highly utilized in areas of lower concentration, especially in brain stem and cortex. Catecholamines were found to be unconjugated in dog brain. DOPAC and HVA were found to exist primarily in the unconjugated form. DOPAC was found to be slightly conjugated in most areas while 10-20% of HVA was present in the conjugated form in most cases.

publication date

  • March 25, 1982

Research

keywords

  • 3,4-Dihydroxyphenylacetic Acid
  • Brain Chemistry
  • Catecholamines
  • Homovanillic Acid
  • Hydroxyindoleacetic Acid
  • Phenylacetates
  • Serotonin

Identity

Scopus Document Identifier

  • 0020064194

Digital Object Identifier (DOI)

  • 10.1016/0006-8993(82)90719-3

PubMed ID

  • 6175382

Additional Document Info

volume

  • 236

issue

  • 2