Epinephrine, norepinephrine, dopamine and serotonin: differential effects of acute and chronic stress on regional brain amines. Academic Article uri icon

Overview

abstract

  • Following acute cold swim stress, hypothalamic epinephrine concentrations were markedly lowered and remained decreased for 24 h, while norepinephrine concentrations were decreased, but returned to baseline within 14 h. With oscillation stress repeated daily for 21 days, hypothalamic norepinephrine, hypothalamic epinephrine, and hippocampal norepinephrine turnover were decreased and absolute concentrations were increased. Repeated stress had little effect on serotonin, dopamine or their metabolites. These results suggest that hypothalamic epinephrine concentration and turnover are particularly responsive to acute and chronic stress. The decreased epinephrine and norepinephrine turnover under chronic stress may be responsible in part for the behavioral and endocrine changes observed in chronically stressed rats.

publication date

  • May 13, 1982

Research

keywords

  • Brain
  • Dopamine
  • Epinephrine
  • Norepinephrine
  • Serotonin
  • Stress, Physiological

Identity

Scopus Document Identifier

  • 0020062094

Digital Object Identifier (DOI)

  • 10.1016/0006-8993(82)90519-4

PubMed ID

  • 6178468

Additional Document Info

volume

  • 239

issue

  • 2