Modulation of lymphokine production by interferon. Academic Article uri icon

Overview

abstract

  • Pretreatments with relatively low (25-250 U/ml) concentrations of interferon (IFN) enhanced while 5000-10 000 U/ml concentrations of IFN inhibited leukocyte inhibitory factor (LIF) and migration inhibitory factor (MIF) production of concanavalin A (Con A) stimulated human leukocytes. The lymphokine regulatory activity of IFN correlated with the antiviral activity of IFN preparations regardless of their specific activity and it showed species specificity. Modulation of lymphokine production depended not only upon the amount of IFN used but also on the length of IFN pretreatment. Blocking of lymphokine production by high concentration of IFN could not be explained by the effect of IFN on cell viability.

publication date

  • January 1, 1980

Research

keywords

  • Interferons
  • Lymphokines

Identity

Scopus Document Identifier

  • 0019239388

Digital Object Identifier (DOI)

  • 10.1089/jir.1980.1.23

PubMed ID

  • 6180042

Additional Document Info

volume

  • 1

issue

  • 1