Reciprocal day/night relationship between serotonin oxidation and N-acetylation products in the rat pineal gland. Academic Article uri icon

Overview

abstract

  • Pineal tryptophan, serotonin [5-hydroxytryptamine (5-HT)], N-acetylserotonin, melatonin, 5-hydroxyindoleacetic acid, 5-hydroxytryptophol, 5-methoxytryptophol, and 5-methoxyindoleacetic acid were measured by high pressure liquid chromatography with electrochemical detection. A complete analysis required less than the equivalent of two rat pineal glands. Samples were obtained at eight time points. A reciprocal physiological relationship was found between oxidation and N-acetylation products of 5-HT. 5-HT and the oxidation products 5-hydroxyindoleacetic acid, 5-hydroxytryptophol, 5-methoxytryptophol, and 5-methoxyindoleacetic acid decreased at night, when the N-acetylation products N-acetylserotonin and melatonin increased. These observations are consistent with the hypothesis that circadian changes in the N-acetylation of 5-HT by indoleamine N-acetyltransferase is the major factor controlling circadian changes in the amounts of 5-HT, and 5-HT oxidation and N-acetylation products in the rat pineal gland.

publication date

  • November 1, 1983

Research

keywords

  • Circadian Rhythm
  • Pineal Gland
  • Serotonin

Identity

Scopus Document Identifier

  • 0020619399

Digital Object Identifier (DOI)

  • 10.1210/endo-113-5-1582

PubMed ID

  • 6194975

Additional Document Info

volume

  • 113

issue

  • 5